Pre and Intrapartum pregnancy factors
This project will expand research on the impact of pre and intra-pregnancy factors (such as hyperandrogenism, maternal obesity, insulin resistance) on development of PCOS and subsequent reproductive, metabolic and psychological complications through our cohort studies. This project will also analyse androgens using mass spectrometry in the Raine and LIMIT cohorts.
Project Lead: Dr Lisa Moran
Impact and mechanisms of adiposity
Adiposity has a bidirectional relationship in PCOS. Women with PCOS are predisposed to weight gain, which in turn increases PCOS prevalence and severity. PCOS is underpinned by intrinsic insulin resistance, exacerbated by extrinsic obesity-related insulin resistance and responds to lifestyle changes. We are exploring the mechanisms of insulin resistance and obesity – including appetite regulation, dietary intake, exercise, sedentary behaviour, thermogenesis, mitochondrial function, inflammation, sympathetic dysfunction and adipokines. Using the cohorts and data pooled under the CRE from new and ongoing clinical trials in PCOS, this project will study natural history, antecedents, modulators, mechanisms and health impacts of obesity and IR in PCOS, including in Indigenous women. This project will also use sophisticated steroid profiling to elucidate the interactions between adiposity and androgens.
Project Lead: Professor Helena Teede